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Drugs used in Rheumatic disorders and Gout For Second Year Diploma in Pharmacy by Pavankumar's Pharmacology edutech classroom


Drugs used in Rheumatic -disorders and Gout For second-year Diploma in Pharmacy/D-Pharm by Pavankumar's Pharmacology edutech classroom. 

Pavankumar'sPharmacology
          Edutech classroom
Rheumatic disorders:-
➡Rheumatic disorders are inflammatory or 
degenerative disorders that affect mainly the 
musculoskeletal system i.e. joints, 
muscles,ligaments, tendons, and bursae. 


These are basically chronic auto-immune 
disorders like rheumatoid-arthritis, 
osteoarthritis, ankylosing spondylitis, 
myositis etc.


Drugs used in rheumatic disorders are:-
01 ➡ NSAIDS like aspirin, Indo-methacin, 
ibuprofen. 
02 ➡corticosteroids
03 ➡ Cytotoxic drugs like azathioprine, 
chlorambucil, Methotrexate. 
04 ➡ Anti-malarials like chloroquine, 
hydroxy Chloroquine.



GOUT :- 

 Gout is a painful inflammatory 
condition that is characterized 
biochemically as a disorder of uric acid metabolism and 
Clinically by hyperuricaemia and 
recurrent attacks of acute arthritis.
➡ If the condition remains untreated 
over a period of years, deposition of 
sodium urate crystals may occur in joints ( gouty arthritis), subcutaneous tissue 
(tophi), and renal parenchyma (gouty nephropathy). 


Drug treatment in gout is used for two purpose:- 

 1. To relieve an acute attack . example:- ➡colchine, 
➡NSAIDs, ➡ corticosteroids

 2. To decrease the amount of uric acid in the body by :-
➡increasing excretion of uric acid by using uricosuric agents like probenecid, sulfinpyrazone. 
➡ Inhibiting the synthesis of uric acid. 

 Example:- 
➡allopurinol.
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Pavankumar's Pharmacology edutech classroom
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